Proteome Sciences plc

Proteome Sciences plc, established in 1993 and based in Cobham, United Kingdom, specializes in delivering contract research services. The company's core expertise lies in the identification, validation, and practical application of protein biomarkers for clients across the United States, the United Kingdom, and the European Union. Its extensive portfolio includes a range of sophisticated proteomic solutions: SysQuant offers comprehensive insights into protein activity within regulatory and signaling pathways. For analyzing cells and tissues without the need for phosphopeptide enrichment, they provide TMT MS2. TMT MS3 is a critical method for biomarker discovery in complex samples, such as plasma, where precise quantification is paramount. The TMT Calibrator enables simultaneous analysis of diseased or treated tissue alongside peripheral fluids. Rapid validation of biomarker candidates is facilitated by TMT SRM, a targeted assay format. Additionally, the company performs SRM assays, a targeted mass spectrometry technique for routine biomarker measurement. Complementing these laboratory services, Proteome Sciences also offers a suite of bioinformatics tools. These include: Proteome Discoverer, utilized for peptide sequencing and TMT quantification. SQuaT, CalDIT, and DIANA, which normalize quantitative data and provide functional annotation for peptides and proteins. FeaST, a visualization tool for assessing data quality, building class identifier models, and generating biomarker candidate lists. FAT, designed to identify variations in biological processes and cellular components. The company's primary clientele comprises pharmaceutical and biotechnology firms, as well as academic research institutions.